Diabetic Neuropathic Pain and Serotonin: What Is New in the Last 15 Years?
نویسندگان
چکیده
The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) is involved in numerous physiological functions and plays a key role pain modulation including neuropathic pain. Diabetic neuropathy common complication of diabetes mellitus often accompanied by chronic Animal models offer relevant tools for studying the pathophysiological mechanisms pharmacological sensitivity diabetic identifying new therapeutic targets. In this review, we report data from preclinical work published over last 15 years on analgesic activity drugs acting serotonergic system, such as noradrenaline reuptake inhibitor (SNRI) antidepressants, involvement certain receptors-in particular 5-HT1A, 5-HT2A/2c 5-HT6 rodent painful neuropathy.
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ژورنال
عنوان ژورنال: Biomedicines
سال: 2023
ISSN: ['2227-9059']
DOI: https://doi.org/10.3390/biomedicines11071924